The 23-time Grand Slam singles winner has stated that this year's U.S. Open will be her last tournament before retiring from tennis competition.
Williams, 40, defeated Danka Kovinic of Montenegro, 6-3, 6-3, in the opening round in front of a galaxy of stars.
On Wednesday, she will face the tournament's No. 2 seed, Estonia's Anett Kontaveit.
When is Serena Williams' next U.S. Open match?
Williams meets the second-seeded Anett Kontaveit in the second round at Arthur Ashe Stadium in Flushing, New York, on Wednesday at roughly 7 p.m. ET.
What channel will Serena Williams' next match be broadcast on?
ESPN will provide exclusive coverage of the U.S. Open in 2022. ESPN2 will broadcast the Serena Williams vs. Anett Kontaveit match.
She has won 23 Grand Slam singles titles throughout her career.